Good Cleaning Validation Practices

Agenda


September 19, 2011

Registration – Continental Breakfast

8:15 – 9:00

Morning Session

  • Welcome and Introductory Remarks
  • Cleaning Validation Defined
  • Design/Development of a Cleaning Process
  • Setting Residue Limits
  • Basic calculations
  • Rinse calculations
  • Other considerations (genotoxics,
    cytotoxics, etc.)
9:00 - 12:30

Lunch

12:30 - 1:30

Afternoon Session

  • Setting Residue Limits (continued)
    • Cleaning agents
    • API’s
    • Clinical trial materials
    • Biotechnology
    • Indirect product contact surfaces
    • Visual inspection
    • Non-uniform contamination
    • Microbial limits
  • Analytical methods to measure residues
    • Specific Methods
    • TOC
    • Newer methods
    • Blanks and controls
    • Method validation
1:30 - 5:00

September 20, 2011

Continental Breakfast

8:30 – 9:00

Morning Session

  • Sampling Methods
    • Direct surface
    • Swab sampling
    • Site selection
    • Rinse sampling
    • Sampling Recovery
  • Protocols
    • Protocol parts
    • Worst cases
    • Dirty equipment hold time
  • Validation strategies
    • Existing processes
    • Grouping strategies
    • Clean equipment hold time
    • Verification
    • Dedicated equipment
    • Campaigns
    • Master plans
9:00 - 12:30

Lunch

12:30 - 1:30

Afternoon Session

  • Validation maintenance
    • Monitoring
    • Preventive maintenance
    • Change control
    • Deviations
    • Revalidation
  • Regulatory guidance documents
    • FDA
    • PIC/S
    • ICH Q7A
    • Other documents
  • Questions & Answers
1:30 - 5:00

Adjornment

5:00